Selective arylthiolane deprotection by singlet oxygen: a promising tool for sensors and prodrugs.
نویسندگان
چکیده
A routine thioketal protecting group reacts rapidly and selectively with singlet oxygen to reveal ketone products in good (aryl 1,3-dithiolane) to excellent (aryl 1,3-oxathiolane) yields. Arylthiolanes are stable to biologically relevant reactive oxygen species and can be used as a light-activated gating mechanism for activating fluorescent sensors or small molecule prodrugs.
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عنوان ژورنال:
- Chemical communications
دوره 51 15 شماره
صفحات -
تاریخ انتشار 2015